What is Pre-implantation Genetic Screening (PGS)?
Pre-implantation Genetic Screening (PGS), also referred to as aneuploidy screening, is a procedure that is used to check for common abnormalities of embryo’s chromosomes conceived through ICSI or IVF. These abnormalities are the major cause of embryo implantation failure that leads to miscarriages. This can further lead to a condition known as Down’s syndrome.
PRC has been an innovator in PGD testing in America, developing a technique known aCGH. You can read more about that HERE.
Who is fit to receive PGS?
Your Dubai fertility doctor will recommend you to receive PGS if:
- Your sperms are at a high risk of experiencing chromosome problems
- Your family history shows that you have a chromosome problems
- You have undergone recurrent miscarriages
- You havegone through several unsuccessful IVF cycles whereby the embryos have been transferred
How does PGS work?
Pre-implantation Genetic Screening procedure works in different ways as shown below:
- First the patient will undergo the normal ICSI or IVF treatment procedure to collect and fertilize the eggs.
- The collected embryo is then taken to the laboratory where it is grown for two to three days until they the initial cells divide to form eight cells.
- Aprofessional embryologist will remove one or two cells from the embryo
- The embryologist will examine the chromosomes to find out how many they are and if they are normal
- The specialist will choose one or two embryos that have normal numbers of chromosomes and transfer them to the woman’s womb for development. Any other unaffected embryos undergo embryo freezing for later use.
- The remaining embryos with abnormal chromosomes are left to perish or they may be used for future research but with the consent of the donors.
This procedure may lead to various variations, but the trophectoderm biopsy method is employed in some cases such as the Comparative Genomic Hybridization (CGH). Quite a number of clinics have adopter the comparative genomic hybridisation (CGH) procedure which allows these centres to carry out some test for abnormalities in the 23 chromosomes. The abnormalities can or cannot be of biological importance though their presence can lower the chances of getting a suitable embryo to complete the transfer.
What are the chances of getting a baby with PGS?
Most of the people who receive PGS are patients with miscarriage history, older patients, or those who produce embryos that are not good enough to be transferred to the woman’s womb. For this reason, the chances of having a baby depend on the nature of the patient.
What are the risks involved in PGS?
Just like any other procedure, PGS treatment has some risks associated with the delicate procedure if the required steps are not followed. These include;
- Some embryos may get damaged in the process of cell removal
- There is a high chance of low-quality embryos that cannot be transferred in the womb once the PGS procedure is performed.
Various diseases show different symptoms as the carrier ages. Ensure you visit your health care provider to detect any signs of a strange disorder. But, remember, there is no guarantee that a miscarriage will not occur even after the PGS has been carried out before embryo transfer.