Ovulation Induction through Fertility Medications in Dubai
Fertility drugs, also called ovulation induction medications, are used to stimulate the follicles of the ovaries so multiple eggs are produced in one cycle. These medications can control the time the ovaries release eggs (ovulation), so intercourse and procedures can be scheduled at the most appropriate time to achieve pregnancy.
What risks are associated with the use of ovulation induction medications?
Ovulation induction fertility medications increase the couple’s chances for multiple births, as well as the development of ovarian cysts. One side effect of these drugs is ovarian hyperstimulation syndrome (OHSS). Symptoms of this syndrome are weight gain, bloating, vomiting, nausea, pelvic pain, and difficulty breathing.
What medications are used for fertility treatment?
The ovulation induction drugs most commonly used include:
- Clomiphene citrate (Serophone and Clomid) – This drug helps women who have irregular, infrequent, or heavy menstrual cycles. Side effects to Clomid include blurred vision, headaches, and hot flashes. This medicine is taken in pill form for five days at the start of a cycle. When women suffer from lack of ovulation, around 80% will ovulate using Clomid, and the conception success rate is 50%. This drug is often combined with intrauterine insemination (IUI) to boost chances of pregnancy.
- Gonadotropins (Bravelle, Follistim, Repronex, GonalF, and Pergonal) – The injectable form of this medication can induce the release of an egg once follicles develop and eggs mature. This drug stimulates “superovulation, which must be monitored using ultrasounds and blood tests. Side effects to gonadotropins include mood swings, bloating, fatigue, abdominal distention, restlessness, and pelvic discomfort.
- Human chorionic gonadotropin (hCG) – This is given at the end of superovulation treatment, so ovulation occurs within 24-36 hours after the injection. Couples should have intercourse at that time, or return to the fertility clinic for IUI. The success rate of using this along with gonadotropin is around 15%, depending on the woman’s age.
- Parlodel – To lower prolactin levels, the fertility specialist may prescribe Parlodel. This drug has few side effects and is inexpensive. It should be taken with meals to prevent nausea and vomiting, and may reduce a pituitary tumor size.
- Metformin (Glucophage) – This drug is used to lower insulin levels. Commonly prescribed to patients with polycystic ovarian syndrome (PCOS), this drug can cause elevated blood pressure, decreased hair loss, and weight loss.
How do ovulation induction fertility drugs work?
These medications stimulate under-producing or inactive ovaries to produce one or more mature eggs. Without ovulation, no egg can be released for fertilization with sperm. For IUI, gentle ovulation induction is used to make 2-3 eggs. When more eggs are required, as with in vitro fertilization (IVF), superovulation is required.
Who is a candidate for fertility medicine?
Ovulation induction is necessary for women who:
- Have inadequate production of follicle-stimulating hormone (FSH) or luteinizing hormone (LH)
- Have polycystic ovarian syndrome (PCOS)
- Have thyroid disorders, diabetes, obesity, or eating disorders
What are the risks of fertility drug use?
A major concern of ovulation induction is an excessive response by ovaries to fertility medications (OHSS). This condition causes changes in vascular permeability and ovarian enlargement, which leads to blood clots, electrolyte disturbances, and fluid in the abdominal cavity.
How do “trigger shots” work?
To induce rupture of the ovarian follicle and increase progesterone production, the fertility specialist can administer a trigger injection. This allows for a LH surge and release of an egg within 24-42 hours.