Going through a fertility treatment is no small task for a couple. It can be a challenge on many levels – physical, mental, emotional and financial. It is important that you prepare yourself in advance so that you can cope with the process better and even turn it into a happy experience. Fertility specialists at the best fertility center in Dubai, PRC Dubai explain what you may experience on the road to parenthood.
It is natural to be a little anxious as you go through your fertility treatment. You are always looking forward to the positive outcome of becoming pregnant. Great fertility clinics such as PRC Dubai advises going in for acupuncture along with your fertility procedure to reduce stress and anxiety and even regulate your ovulation and hormonal balance.
PEOPLE MAY BE INSENSITIVE
Most people don’t have adequate or correct information about fertility treatments. They may say negative or insensitive things about you or the process. Be prepared for that. Support each other as a couple while you are going through a fertility treatment. Ask your fertility doctor at PRC Dubai for the right information. Experts and staff at PRC Dubai would be happy to answer any queries you may have on the topic and they are the right people to ask.
TRUST THE PROCESS
Once you have chosen a great fertility treatment center such as PRC Dubai, trust the process. The treatment may be successful in a single go or there may be setbacks. Do not treat a single setback as failure. Your fertility doctor at PRC Dubai is highly qualified and experienced in fertility medicine and the staff is trained to take care of you while you go through the treatment. Have faith in the journey and the rest will follow.
The journey to parenthood may not be easy for everyone. The emotional drain while you are struggling to become a parent takes a toll on many couples. Thanks to fertility medicine, such couples now have a shot at experiencing the joys of parenthood. The doctors at the best fertility clinic in Middle East, PRC Dubai, describe five telltale signs that you need to see a fertility doctor.
Recurrent loss of pregnancy should see a fertility doctor immediately who would determine the cause and advise appropriate treatment. Causes of recurrent miscarriages could range from genetic to metabolic. Doctors at the top fertility clinic in Middle East, PRC Dubai, treat recurrent loss of pregnancy with medications, hormonal imbalance correction or minimally invasive surgery.
IRREGULAR MENSTRUAL CYCLE
If you are facing difficulty conceiving and have irregular menstrual cycle, it’s a big sign that you should seek advice from a fertility specialist. Irregular menstrual cycle indicates endometriosis, uterine fibroids, pelvic inflammatory disease and stress.This can interfere with the ability to conceive. Fertility doctors at PRC Dubai will diagnose the underlying cause and treat it with methods to regulate your menstrual cycle so that you can get pregnant naturally.
PCOS (Polycystic Ovary Syndrome)
PCOS is a hormonal imbalance that contributes to infertility in 40 percent of the cases. It may also cause spontaneous abortion. Various medications are used to treat PCOS at top Dubai fertility clinic, PRC. Your fertility specialist will diagnose the condition and correct imbalances to regulate your menstrual cycle and improving your chances of conception.
On day 14 of a normal menstrual cycle, an egg is released from the ovary in a process called ovulation. The egg goes into the fallopian tube where it is fertilized. After remaining in the tube for several days, the egg develops into an embryo, which enters the uterus and implants into the endometrium (uterine lining). With in vitro fertilization, the sperm does not have to travel to the fallopian tube to fertilize the egg.
IVF is an advanced reproductive technology (ART) process first used successfully in England in 1978. In the beginning, IVF was only used to treat infertility related to blocked fallopian tubes. Now, IVF has evolved to be an effective treatment for many causes of infertility. IVF can be used when other treatments fail, and many fertility clinics now report a 50% success rate using IVF.
Indications for IVF
Many diagnoses lead a couple to undergo IVF. The most common indications for IVF include:
Male factor infertility
Fallopian tube damage
Advanced maternal age
Recurrent pregnancy loss
The IVF Procedure
With the IVF process, the ovaries are stimulated using certain medications so they mature multiple eggs. Vaginal ultrasounds and blood testing is done to monitor the development of the eggs. Once eggs are mature, they are removed from each ovary using a minor surgical procedure. Once retrieved, the eggs are placed into a petri dish and exposed to the male partner’s sperm. After several days, the egg cells divide and become embryos. After determining which embryos are viable and of high-quality, the embryos are placed into the woman’s uterus using a small catheter inserted through the cervix. Extra embryos are frozen (cryopreserved) for later use.
The IVF laboratory procedures involved include:
Intracytoplasmic sperm injection (ICSI) – If fertilization is problematic due to sperm shape or motility issues, ICSI is used. Donor sperm may be used in the case of a low sperm count. With ICSI, a single sperm is injected into the egg using microtools and microscopic technology.
Assisted hatching – When the outer layer of the embryo (zona pellucida) is thick, the embryo may have trouble breaking free, or “hatching.” Assisted hatching involves making a tiny hole in the shell before transferring to the uterus. This allows embryos to implant into the uterine lining easily.
Embryo freezing – Cryopreservation (egg freezing) is done 3-8 days after the embryos form. These embryos have the potential to become successful pregnancies later on.
Preimplantation genetic diagnosis (PGD) – This form of testing involves removing a single cell from the developing embryo to analyze it for chromosomal and genetic abnormalities.
Egg freezing – For women who do not wish to become pregnant until years later, egg freezing is an option. Women who are candidates include those in their 30s who wish to delay child bearing, those with cancer who are going to receive chemotherapy, and those who are having IVF and do not wish to freeze embryos.
Trophectoderm biopsy – A new technique used to screen embryos and to select those most likely to result in pregnancy. Cells are removed from the embryo during the blastocyst stage. This test is used for women with recurrent pregnancy losses, as well as those at risk for chromosomal abnormalities.
PRC Dubai offers in vitro fertilization at a first rate fertility center in Dubai Healthcare City. After two decades of IVF success in the US, PRC is now open in Dubai. With an in-house laboratory, the Dubai fertility clinic offers exceptional and comprehensive treatment options. Call us today!
Preimplantation genetic testing, also called preimplantation genetic diagnosis (PGD), is a process of removing a cell from an embryo for genetic testing. This is done at PRC Dubai fertility center to assess for diseases and conditions that could interfere with the embryo’s survival once it is introduced into the uterus. PGD is used in the in vitro fertilization (IVF) process.
History of PGD
The first IVF procedure was completed in 1978. Years later, scientists began testing the embryo for potential health problems as well as chromosomal abnormalities. PGD was used in humans in 1990, and many improvements have occurred with PGD in the last 25 years. Genetic technologies used on cells removed from embryos and embryo biopsy have improved drastically over the last couple of decades.
Stages of Egg and Embryo Development
Three basic stages exist at which embryos or eggs may be biopsied to remove cells for testing. These include:
Polar body – This is an early stage where the polar body of the egg is removed and tested. A mature human oocyte (egg) has one polar body, and a fertilized egg has two polar bodies. This technique does not alter the egg or embryo so that it cannot implant into the uterus or develop into a fetus. However, there is the chance of damage to the developing embryo with polar body biopsy.
Cleavage stage – Day three of the embryo’s development is stage three. At this point, the embryo has 6-10 cells. Removal of the outer shell (zona pellucida) is performed so 1-2 cells can be removed for testing. Stage three development is important for the embryo’s development, so many IVF programs are not performing this technique.
Blastocyst stage – The trophectoderm biopsy is the technique performed during the blastocyst stage of embryo development. After the embryo is formed into a multi-cell mass (trophectoderm), it has a fluid-filled cavity. This biopsy involves making a small hole in the shell of the embryo so several cells can be removed for testing.
The best fertility clinics for PGD are the ones with the best IVF success rates. The clinic should have an excellent culture system in order to obtain the maximum number of quality cells for biopsy. The clinic should also be skilled in embryo biopsy and blastocyst freezing, as well as successful in thawing frozen eggs and embryos.
Candidates for PGD
The most common reason for preimplantation genetic testing is advanced age. Women of advancing age have increased rates of chromosomally abnormal eggs, which develop into abnormal embryos. Five main types of clients should use PGD. These include clients who:
Are having IVF with female age of 38 years or older
Have repeated IVF failure, defined as three or more failed attempts
Have a family history of inherited genetic diseases
Are carriers of chromosomal translocations
Have had recurrent miscarriages
Rates of Chromosomal Abnormality
The percentage of eggs with some type of chromosomal abnormality does increase as the woman ages. Approximately 45% of human embryos have some form of chromosomal abnormality. By testing the embryos available for transfer, we can avoid use of ones with abnormalities and choose healthy, high-quality embryos for transfer the woman’s uterus. PGD testing of early embryos will increase the chances of a successful pregnancy.
Technology used to Assess Chromosomes
There are three technologies currently being used for assessment of chromosomal abnormalities. These are:
PRC Dubai is the top fertility center in Dubai. After two successful decades of treatment at several metro Los Angeles fertility centers, PRC is now open in Dubai Healthcare City! Call us today at 800-4544.
Women often delay childbearing due to personal circumstances. Because egg quality declines with age, women now have the option of egg freezing so the eggs can be fertilized and implanted at a later date. This form of assisted reproductive technology enables women to cryopreserve (freeze) eggs when they are at their healthiest.
The Natural Egg Reserve
On average, a woman has around 600,000 eggs, which are present at birth. This supply diminishes at a rate of 1,000 per month throughout the lifespan. This egg reserve decline is often referred to as a woman’s biological clock. The loss of eggs continues, regardless of pregnancy, absence of menses, or if the woman is taking oral contraceptives. The rate of egg loss accelerates when a woman is in her late 30s and early 40s. By midlife (43-47 years of age), a woman usually loses her natural ability to have children. What is more important, egg quality diminishes with time, and chromosome defects and miscarriages are more common with a later age of pregnancy.
Preparing for Egg Freezing
Women interested in freezing eggs will first undergo a series of fertility tests to assess reproductive potential and readiness for IVF. This involves:
Initial evaluation of ovarian reserve – The consultation with the fertility specialist involves taking a medical history, conducting a physical examination, and assessing the rate of future success. Testing include assessing follicle-stimulating hormone (FSH) levels, estrogen levels, antral follicle count, and anti-Mullerian hormone (AMH) levels.
Egg retrieval process – This process involves taking fertility medications to stimulate follicle growth so multiple eggs are produced. Ultrasound and blood levels are used to monitor progress, and eggs are retrieved during a simple office procedure.
Egg preservation – The retrieved eggs are then processed through a rapid freezing process called vitrification. The frozen eggs are cryopreserved until they are needed. It is important for the client to maintain contact with the fertility clinic so the eggs will not be abandoned.
Creating Embryos using Frozen Eggs
The process of using frozen eggs involves:
Thawing – When the client decides to have a child, the eggs can be thawed in the laboratory. Thawing occurs on the day the eggs are to be fertilized and should be synchronized with the woman’s cycle. Around 90% of the frozen eggs survive the freeze-to-thaw process.
Fertilization – Thawed eggs are then fertilized in our laboratory using intracytoplasmic sperm injection (ICSI), where a single sperm is strategically placed into each egg. ICSI is required for fertilization because the protein coat around the egg becomes hardened through the freezing process. Around 70% of the injected eggs are expected to become fertilized.
Embryo culture – After fertilization, the eggs remain in the laboratory for three to five days to develop into embryos. While not all develop into embryos, the number of eggs that survive and progress is related to the woman’s age at the time of egg freezing.
Embryo transfer – The number of embryos transferred to the client’s uterus depends on her age at the time of egg freezing. Younger women have greater likelihood of implantation, so fewer embryos are transferred. The transfer is done using a tiny insertion catheter and ultrasound guidance.
PRC Dubai offers first rate fertility treatment in Dubai Healthcare City. After 25 years of success in the US, PRC is now offering state-of-the-art options in the Middle East! Here’s a video on Egg Freezing: